肉毒杆菌毒素经肌肉注射对猴子的全身毒性
Systemic toxicity of botulinum toxin by intramuscular injection in the monkey.
作者信息
Scott A B, Suzuki D
机构信息
Smith-Kettlewell Eye Research Institute, Pacific Presbyterian Medical Center, San Francisco, California.
出版信息
Mov Disord. 1988;3(4):333-5. doi: 10.1002/mds.870030409.
PMID:3211180
Abstract
Botulinum toxin (Oculinum) was injected intramuscularly into eight monkeys. The LD50 dose is estimated to be approximately 39 U/kg body weight. The lowest dose that caused systemic toxicity, 33 U/kg, was close to the fatal dose range, 38-42 U/kg.
摘要
将肉毒杆菌毒素（眼用肉毒毒素）肌肉注射到八只猴子体内。半数致死剂量估计约为39单位/千克体重。引起全身毒性的最低剂量为33单位/千克，接近致死剂量范围38 - 42单位/千克。
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