Karšaj Igor, Humphrey Jay D
Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, I. Lučića 5, Croatia.
Mech Mater. 2012 Jan 1;44:110-119. doi: 10.1016/j.mechmat.2011.05.006.
Adaptations of large arteries to sustained alterations in hemodynamics that cause changes in both caliber and stiffness are increasingly recognized as important initiators or indicators of cardiovascular risk to high flow, low resistance organs such as the brain, heart, and kidney. There is, therefore, a pressing need to understand better the underlying causes of geometric and material adaptations by large arteries and the associated time courses. Although such information must ultimately come from well designed experiments, mathematical models will continue to play a vital role in the design of these experiments and their interpretation. In this paper, we present a new multilayered model of the time course of basilar artery growth and remodeling in response to sustained alterations in blood pressure and flow. We show, for example, that single- and multi-layered models consistently predict similar changes in caliber and wall thickness, but multilayered models provide additional insight into other important metrics such as the residual stress related opening angle and the axial prestress, both of which are fundamental to arterial homeostasis and responses to injury or insult.
大动脉对血流动力学持续改变的适应性会导致管径和硬度的变化，这越来越被认为是对脑、心脏和肾脏等高流量、低阻力器官心血管风险的重要引发因素或指标。因此，迫切需要更好地理解大动脉几何和材料适应性的潜在原因以及相关的时间进程。尽管此类信息最终必须来自精心设计的实验，但数学模型将继续在这些实验的设计及其解读中发挥至关重要的作用。在本文中，我们提出了一种新的多层模型，用于描述基底动脉在血压和血流持续改变时的生长和重塑时间进程。例如，我们表明单层和多层模型一致地预测了管径和壁厚的相似变化，但多层模型还能进一步深入了解其他重要指标，如与残余应力相关的开口角度和轴向预应力，这两者对于动脉内环境稳定以及对损伤或刺激的反应都至关重要。
