沉默信息调节因子1在肿瘤发生中的作用。
The role of SIRT1 in tumorigenesis.
作者信息
Li Kai, Luo Jianyuan
机构信息
Department of Medical & Research Technology, Department of Pathology, School of Medicine, University of Maryland, AHB 405A, 100 Penn Street, Baltimore, MD 21201.
出版信息
N Am J Med Sci (Boston). 2011;4(2):104-106. doi: 10.7156/v4i2p104.
Abstract
NAD-dependent Class III histone deacetylase SIRT1 is a multiple functional protein and has been demonstrated critically involved in stress response, cellular metabolism and aging through deacetylating variety of substrates including p53, forkhead transcription factors, PGC-1α, NF-κB, Ku70 and histones. Increasing evidences indicate that SIRT1 plays a complex role in tumorigenesis with functions in both tumor promoting and tumor suppressing. This review provides an overview of current knowledge of SIRT1 and its controversies regarding the functions of SIRT1 in tumorigenesis.
摘要
烟酰胺腺嘌呤二核苷酸（NAD）依赖的Ⅲ类组蛋白去乙酰化酶SIRT1是一种多功能蛋白，已证明它通过使包括p53、叉头转录因子、PGC-1α、NF-κB、Ku70和组蛋白在内的多种底物去乙酰化，在应激反应、细胞代谢和衰老过程中发挥关键作用。越来越多的证据表明，SIRT1在肿瘤发生中发挥复杂作用，具有促进肿瘤和抑制肿瘤的功能。本文综述了目前关于SIRT1的知识及其在肿瘤发生中功能的争议。
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