Otsuka Ryota, Hayano Koichi, Matsubara Hisahiro
Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
World J Gastrointest Oncol. 2022 Apr 15;14(4):794-807. doi: 10.4251/wjgo.v14.i4.794.
Esophageal cancer (EC) is a malignant cancer that still has a poor prognosis, although its prognosis has been improving with the development of multidisciplinary treatment modalities such as surgery, chemotherapy and radiotherapy. Therefore, identifying specific molecular markers that can be served as biomarkers for the prognosis and treatment response of EC is highly desirable to aid in the personalization and improvement of the precision of medical treatment. Sirtuins are a family of nicotinamide adenine dinucleotide (NAD+)-dependent proteins consisting of seven members (SIRT1-7). These proteins have been reported to be involved in the regulation of a variety of biological functions including apoptosis, metabolism, stress response, senescence, differentiation and cell cycle progression. Given the variety of functions of sirtuins, they are speculated to be associated in some manner with cancer progression. However, while the role of sirtuins in cancer progression has been investigated over the past few years, their precise role remains difficult to characterize, as they have both cancer-promoting and cancer-suppressing properties, depending on the type of cancer. These conflicting characteristics make research into the nature of sirtuins all the more fascinating. However, the role of sirtuins in EC remains unclear due to the limited number of reports concerning sirtuins in EC. We herein review the current findings and future prospects of sirtuins in EC.
食管癌（EC）是一种恶性肿瘤，尽管随着手术、化疗和放疗等多学科治疗方式的发展，其预后有所改善，但预后仍然较差。因此，迫切需要鉴定出能够作为食管癌预后和治疗反应生物标志物的特定分子标志物，以帮助实现个性化治疗并提高医疗精准度。沉默调节蛋白是一类依赖烟酰胺腺嘌呤二核苷酸（NAD+）的蛋白质家族，由七个成员（SIRT1 - 7）组成。据报道，这些蛋白质参与多种生物学功能的调节，包括细胞凋亡、代谢、应激反应、衰老、分化和细胞周期进程。鉴于沉默调节蛋白的多种功能，推测它们在某种程度上与癌症进展有关。然而，尽管在过去几年中已经对沉默调节蛋白在癌症进展中的作用进行了研究，但由于它们具有促癌和抑癌特性，具体取决于癌症类型，其确切作用仍难以确定。这些相互矛盾的特性使得对沉默调节蛋白本质的研究更加引人入胜。然而，由于关于食管癌中沉默调节蛋白的报道数量有限，其在食管癌中的作用仍不清楚。我们在此综述了食管癌中沉默调节蛋白的当前研究结果和未来前景。
