Deng Wanyan, Tang Xiemei, Hou Manmei, Li Chunmei, Xie Jianping
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Enviroment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, China.
Crit Rev Eukaryot Gene Expr. 2011;21(4):337-45. doi: 10.1615/critreveukargeneexpr.v21.i4.40.
Tuberculosis remains a worldwide health concern, largely due to the emergence of multi-drug-resistant (MDR) and extensive-drug-resistant (XDR) Mycobacterium tuberculosis co-infection with HIV. The exact mechanism of Mycobacterium virulence, pathogenesis, and persistence is not fully understood. The hallmark of tuberculosis, granulomas are promoted by Mycobacterium virulence factors, and they have long been considered a structural advantage to the host. However, this traditional view has been challenged recently, largely due to the evidence originating from the M. marinum-zebrafish model. As a genetically tractable model, zebrafish provide unprecedented opportunities to address the pathogenesis of tuberculosis from a systems biology perspective. The latest data from this model are summarized in this review, special attention is given to the shared pathway and network between zebrafish and humans. This research serves to deepen our understanding of this complex process and to promote the discovery of better countermeasures against tuberculosis.
结核病仍然是一个全球性的健康问题，这主要归因于耐多药（MDR）和广泛耐药（XDR）结核分枝杆菌与HIV的合并感染。结核分枝杆菌毒力、发病机制和持续存在的确切机制尚未完全明确。作为结核病的标志，肉芽肿由结核分枝杆菌毒力因子促成，长期以来它们一直被认为对宿主具有结构优势。然而，这一传统观点最近受到了挑战，主要是由于来自海分枝杆菌-斑马鱼模型的证据。作为一种具有遗传易处理性的模型，斑马鱼为从系统生物学角度研究结核病的发病机制提供了前所未有的机会。本综述总结了该模型的最新数据，特别关注了斑马鱼与人类之间的共同途径和网络。这项研究有助于加深我们对这一复杂过程的理解，并促进发现更好的结核病应对措施。
