Gamel J W, McLean I W, Rosenberg S H
Department of Ophthalmology, University of Louisville, KY.
Stat Med. 1990 Aug;9(8):999-1006. doi: 10.1002/sim.4780090814.
We obtained maximum likelihood estimates (MLEs) of the proportion cured pi c and mean log survival time mu t for a sample of 4355 patients with intraocular melanoma whose survival times subsequent to treatment were assumed to follow a log-normal distribution. Following stratification by tumour size, MLEs of pi c and mu t derived for each stratum correlate inversely with tumour size. We then expressed pi c and mu t as continuous functions of tumour size and calculated MLEs for the parameters of these functions from the entire sample. This investigation documents for ocular melanoma a significant relationship of tumour size to both cured fraction and mean log survival time.
我们对4355例眼内黑色素瘤患者的样本获得了治愈比例πc的最大似然估计值（MLEs）和平均对数生存时间μt，假定其治疗后的生存时间服从对数正态分布。按肿瘤大小分层后，为每个分层得出的πc和μt的MLEs与肿瘤大小呈负相关。然后，我们将πc和μt表示为肿瘤大小的连续函数，并从整个样本中计算这些函数参数的MLEs。这项研究证明，对于眼内黑色素瘤，肿瘤大小与治愈比例和平均对数生存时间均存在显著关系。
