Gamel J W, McLean I W, Greenberg R A
Department of Ophthalmology, University of Louisville School of Medicine, Kentucky.
Cancer. 1988 Feb 1;61(3):574-9. doi: 10.1002/1097-0142(19880201)61:3<574::aid-cncr2820610325>3.0.co;2-9.
In a selected group of 3680 patients treated by ocular excision for uveal melanoma, 1178 deaths were attributed to this tumor during 20 years following ocular excision. Survival time was divided into intervals containing an equal number of deaths, and coefficients of the Cox statistical model were independently derived for each interval. This analysis revealed a statistically significant decline over time in the prognostic value of largest tumor dimension (LTD) and Callender cell type (CT). Mathematical considerations suggest that the prognostic value of parameters derived from other cancers may also decline with time following excision of the primary tumor.
在一组经眼球摘除术治疗葡萄膜黑色素瘤的3680例患者中，1178例患者在眼球摘除术后20年内死于该肿瘤。将生存时间划分为死亡人数相等的区间，并针对每个区间独立推导Cox统计模型的系数。该分析显示，最大肿瘤直径（LTD）和卡伦德细胞类型（CT）的预后价值随时间有统计学意义的下降。数学分析表明，源自其他癌症的参数的预后价值在原发肿瘤切除后也可能随时间下降。
