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睫状神经营养因子与视网膜。

CNTF and retina.

机构信息

Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.

出版信息

Prog Retin Eye Res. 2012 Mar;31(2):136-51. doi: 10.1016/j.preteyeres.2011.11.005. Epub 2011 Dec 10.

DOI:10.1016/j.preteyeres.2011.11.005
PMID:22182585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3288688/
Abstract

Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for neuroprotection of the retina. A large body of evidence demonstrates that CNTF promotes rod photoreceptor survival in almost all animal models. Recent studies indicate that CNTF also promotes cone photoreceptor survival and cone outer segment regeneration in the degenerating retina and improves cone function in dogs with congenital achromotopsia. In addition, CNTF is a neuroprotective factor and an axogenesis factor for retinal ganglion cells (RGCs). This review focuses on the effects of exogenous CNTF on photoreceptors and RGCs in the mammalian retina and the potential clinical application of CNTF for retinal degenerative diseases.

摘要

睫状神经营养因子 (CNTF) 是研究最多的神经营养因子之一，可用于保护视网膜神经。大量证据表明，CNTF 可促进几乎所有动物模型中的杆状光感受器存活。最近的研究表明，CNTF 还可促进变性视网膜中的锥状光感受器存活和锥状外节再生，并改善先天性色盲犬的锥状功能。此外，CNTF 是视网膜神经节细胞 (RGC) 的神经营养因子和轴突发生因子。本综述重点介绍外源性 CNTF 对哺乳动物视网膜中光感受器和 RGC 的作用，以及 CNTF 治疗视网膜退行性疾病的潜在临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/9ebfb3fb718d/nihms344305f9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/caee7173b33a/nihms344305f5.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/a50a4351e9dc/nihms344305f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/9ebfb3fb718d/nihms344305f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/adfa670f3156/nihms344305f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/51beaa5d10e0/nihms344305f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/efba3080bc4f/nihms344305f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/a0a9b593890c/nihms344305f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/caee7173b33a/nihms344305f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/c7cfeeeaeacd/nihms344305f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/fa2e8328b53a/nihms344305f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/a50a4351e9dc/nihms344305f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e027/3288688/9ebfb3fb718d/nihms344305f9.jpg

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