The Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA.
Neurobiol Dis. 2012 May;46(2):255-62. doi: 10.1016/j.nbd.2011.12.008. Epub 2011 Dec 13.
Cortical and subcortical dysfunction in schizophrenia includes altered expression of RNA and proteins involved in neurotransmission, metabolism, myelination and other functions. The molecular mechanisms underlying this type of alteration remain largely unknown. Here, we summarize findings from postmortem brain studies and argue that transcriptional dysregulation, including changes in DNA and histone modifications involved in epigenetic control of gene expression, as well as microRNA-mediated post-transcriptional mechanisms contribute to the neurobiology of schizophrenia.
精神分裂症的皮质和皮质下功能障碍包括涉及神经传递、代谢、髓鞘形成和其他功能的 RNA 和蛋白质表达的改变。这种改变的分子机制在很大程度上仍然未知。在这里，我们总结了尸检大脑研究的发现，并认为转录失调，包括涉及基因表达的表观遗传控制的 DNA 和组蛋白修饰的变化，以及 microRNA 介导的转录后机制，都有助于精神分裂症的神经生物学。
