Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil.
Neurosci Res. 2012 Mar;72(3):270-4. doi: 10.1016/j.neures.2011.12.001. Epub 2011 Dec 13.
We evaluated the involvement of paraventricular nucleus (PVN) in the changes in mean arterial pressure (MAP) and heart rate (HR) during an orthostatic challenge (head up tilt, HUT). Adult male Wistar rats, instrumented with guide cannulas to PVN and artery and vein catheters were submitted to MAP and HR recording in conscious state and induction of HUT. The HUT induced an increase in MAP and HR and the pretreatment with prazosin and atenolol blocked these effects. After inhibition of neurotransmission with cobalt chloride (1 mM/100 nl) into the PVN the HR parameters did not change, however we observed a decrease in MAP during HUT. Our data suggest the involvement of PVN in the brain circuitry involved in cardiovascular adjustment during orthostatic challenges.
我们评估了室旁核（PVN）在直立挑战（头高位倾斜，HUT）期间平均动脉压（MAP）和心率（HR）变化中的作用。成年雄性 Wistar 大鼠，用导管插入 PVN 和动脉及静脉导管，在清醒状态下记录 MAP 和 HR，并进行 HUT 诱导。HUT 引起 MAP 和 HR 的增加，而预先给予普萘洛尔和阿替洛尔可阻断这些作用。用氯化钴（1mM/100nl）抑制 PVN 中的神经传递后，HR 参数没有变化，但我们观察到 HUT 期间 MAP 下降。我们的数据表明，PVN 参与了直立挑战时心血管调节的脑回路。
