Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
J Clin Invest. 2012 Jan;122(1):19-22. doi: 10.1172/JCI61453. Epub 2011 Dec 19.
Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases. Hence, great efforts have been made to develop drugs targeting the EET pathway. Some of these agents are currently under evaluation in clinical trials for treatment of hypertension and diabetes. In this issue of the JCI, Panigrahy et al. evaluate in a systematic way the role of CYP epoxygenases and the metabolites they generate in cancer progression. Their findings, along with previous studies, raise concerns about using these drugs in humans.
环氧二十碳三烯酸（EETs）是细胞色素 P450（CYP）加氧酶从花生四烯酸生成的，对某些心血管和肾脏疾病有有益作用。因此，人们做出了巨大努力来开发针对 EET 途径的药物。其中一些药物目前正在临床试验中评估用于治疗高血压和糖尿病。在本期 JCI 中，Panigrahy 等人系统评估了 CYP 加氧酶及其生成的代谢产物在癌症进展中的作用。他们的研究结果与之前的研究一起，引起了人们对在人类中使用这些药物的担忧。
