Curso de Fonoaudiologia, Faculdade de Ciências Médicas, Unicamp.
Braz J Otorhinolaryngol. 2011 Nov-Dec;77(6):784-90. doi: 10.1590/S1808-86942011000600016.
Hearing is one of the main ways with which one person can contact the external world; it plays a key role in their integration with society.
The objective of this study was to analyze the results of the hearing, medical and genetic evaluation of high-risk infants who failed the newborn hearing screening.
Clinical and experimental study. We assessed thirty-eight neonates, with ages between one and six months. The infants underwent the following procedures: medical interview; immittance testing; Brainstem Auditory Evoked Potential; Transient Evoked Otoacoustic Emission and otorhinolaryngological evaluation. DNA extraction from the oral mucosa was performed for genetic studies using the protocol method adapted from the Human Genetics Lab of the CBMEG/UNICAMP.
Regarding gender and presence of risk factors, significant statistically differences were not found in normal hearing infants and in those with hearing loss. Concerning gestational age, term infants were more affected by hearing loss. Hearing loss was identified in 58% of the sample, conduction hearing loss represented 31.5% (12/38) and neurossensory 28.9% of cases. There were none of the genetic mutations most commonly seen in cases with a genetic etiology.
Hearing loss was identified in the majority of High-risk infants.
听力是一个人联系外部世界的主要方式之一；它在他们与社会的融合中起着关键作用。
本研究旨在分析新生儿听力筛查未通过的高危婴儿的听力、医学和遗传评估结果。
临床和实验研究。我们评估了 38 名年龄在 1 至 6 个月之间的新生儿。婴儿接受了以下程序：医学访谈；声导抗测试；脑干听觉诱发电位；瞬态诱发耳声发射和耳鼻喉科评估。使用从 CBMEG/UNICAMP 的人类遗传学实验室改编的方案方法从口腔黏膜中提取 DNA 进行遗传研究。
关于性别和危险因素的存在，在听力正常的婴儿和听力损失的婴儿之间没有发现显著的统计学差异。关于胎龄，足月婴儿听力损失的发生率更高。在样本中发现 58%的听力损失，传导性听力损失占 31.5%（12/38），神经感觉听力损失占 28.9%。没有发现最常见的具有遗传病因的基因突变。
大多数高危婴儿都有听力损失。
