Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
J Pediatr. 2012 May;160(5):743-50. doi: 10.1016/j.jpeds.2011.10.037. Epub 2011 Dec 17.
To assess the mortality experience of participants in the Third Harvard Growth Study (1922-1935) who provided ≥ 8 years of growth data.
A total of 1877 participants provided an average of 10.5 body mass index measurements between age 6 and 18 years. Based on these measurements, the participants were classified as ever overweight or ever >85th percentile for height in childhood. Age at peak height velocity was used to indicate timing of overweight relative to puberty. Relative risks of all-cause and cause-specific mortality according to measures of childhood growth were estimated using Cox proportional hazards survival analysis.
For women, ever being overweight in childhood increased the risks of all-cause and breast cancer death; the risk of death from ischemic heart disease was increased in men. Men with a first incidence of overweight before puberty were significantly more likely to die from ischemic heart disease; women in the same category were more likely to die from all causes and from breast cancer.
We find evidence of long-term effects of having ever been overweight, with some evidence that incidence before puberty influences the pattern of risk.
评估曾提供≥8 年生长数据的第三次哈佛生长研究（1922-1935）参与者的死亡率。
共有 1877 名参与者在 6 至 18 岁期间平均提供了 10.5 次体重指数测量值。根据这些测量值，参与者被归类为曾超重或曾在儿童时期身高处于>85 百分位。使用身高生长高峰年龄来表示超重与青春期的相对时间。使用 Cox 比例风险生存分析估计根据儿童生长指标衡量的全因和特定原因死亡率的相对风险。
对于女性，儿童时期超重会增加全因和乳腺癌死亡的风险；男性超重会增加缺血性心脏病死亡的风险。青春期前首次超重的男性死于缺血性心脏病的风险显著增加；同一类别的女性死于全因和乳腺癌的风险更高。
我们发现超重的长期影响证据，一些证据表明青春期前的发病会影响风险模式。
