Department of Otolaryngology Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, 8091 Zurich, Switzerland.
Eur Arch Otorhinolaryngol. 2012 Aug;269(8):1917-22. doi: 10.1007/s00405-011-1881-7. Epub 2011 Dec 21.
Epistaxis and alcohol overconsumption are frequently encountered in patients admitted to emergency wards. The aim of the study was to analyze indirect markers of alcohol overconsumption in epistaxis patients and evaluate its role as a risk factor. In a cohort of 510 epistaxis patients indirect markers of alcohol overuse were measured including the mean corpuscular volume (MCV), gamma glutamyltransferase (GGT), aspartate aminotransferase and alanine aminotransferase. The results were compared to the normal findings in literature. Pathologic mean levels of GGT were found in epistaxis patients. Almost 5% had macrocytosis and MCV correlated positively with liver enzyme levels. Platelet counts were negatively correlated with both corpuscular volumes and liver enzymes. Indirect markers of alcohol overconsumption were found to be elevated in epistaxis patients. These results suggest that a subgroup of epistaxis patients overconsumes alcoholic beverages supporting the idea of alcohol abuse being a risk factor in epistaxis. Questioning about drinking habits should be employed and help offered to affected patients.
鼻出血和酗酒在急诊病房的患者中经常遇到。本研究旨在分析鼻出血患者中酒精过量的间接标志物，并评估其作为危险因素的作用。在 510 例鼻出血患者的队列中，测量了间接的酒精滥用标志物，包括平均红细胞体积（MCV）、γ-谷氨酰转移酶（GGT）、天冬氨酸转氨酶和丙氨酸转氨酶。结果与文献中的正常发现进行了比较。鼻出血患者的 GGT 水平异常升高。几乎有 5%的患者出现巨红细胞症，MCV 与肝酶水平呈正相关。血小板计数与细胞体积和肝酶均呈负相关。鼻出血患者的酒精过量间接标志物升高。这些结果表明，亚组鼻出血患者酗酒，支持酒精滥用是鼻出血的危险因素的观点。应该询问有关饮酒习惯的问题，并为受影响的患者提供帮助。
