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Front Biosci (Landmark Ed). 2011 Jan 1;16(2):531-8. doi: 10.2741/3703.
2
Apoptosis and colorectal cancer: implications for therapy.细胞凋亡与结直肠癌：对治疗的启示
Trends Mol Med. 2009 May;15(5):225-33. doi: 10.1016/j.molmed.2009.03.003. Epub 2009 Apr 8.
3
Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials.胰岛素样生长因子-I受体通路抑制剂的早期药物研发：来自首批临床试验的经验教训
Mol Cancer Ther. 2008 Sep;7(9):2575-88. doi: 10.1158/1535-7163.MCT-08-0265.
4
Inducing apoptosis of human colon cancer cells by an IGF-I D domain analogue peptide.通过胰岛素样生长因子-I D结构域类似肽诱导人结肠癌细胞凋亡。
Mol Cancer. 2008 Feb 8;7:17. doi: 10.1186/1476-4598-7-17.
5
Role of insulin-like growth factor binding protein-4 in prevention of colon cancer.胰岛素样生长因子结合蛋白-4在预防结肠癌中的作用。
World J Surg Oncol. 2007 Nov 7;5:128. doi: 10.1186/1477-7819-5-128.
6
The somatomedin hypothesis 2007: 50 years later.2007年的生长调节素假说：50年后。
J Clin Endocrinol Metab. 2007 Dec;92(12):4529-35. doi: 10.1210/jc.2007-0526. Epub 2007 Nov 6.
7
Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors.抗胰岛素样生长因子-I受体单克隆抗体CP-751,871用于难治性实体瘤患者的I期剂量递增研究。
Clin Cancer Res. 2007 Oct 1;13(19):5834-40. doi: 10.1158/1078-0432.CCR-07-1118.
8
Increased apoptosis and decreased proliferation of colorectal cancer cells using insulin-like growth factor binding protein-4 gene delivered locally by gene transfer.
Colorectal Dis. 2007 Sep;9(7):625-31. doi: 10.1111/j.1463-1318.2006.01190.x.
9
A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.一种新型、强效且选择性的胰岛素样生长因子-I受体激酶抑制剂在体外阻断胰岛素样生长因子-I受体信号传导，并在体内抑制胰岛素样生长因子-I受体依赖性肿瘤生长。
Mol Cancer Ther. 2007 Aug;6(8):2158-67. doi: 10.1158/1535-7163.MCT-07-0070. Epub 2007 Aug 1.
10
Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer.胰岛素样生长因子结合蛋白-4基因疗法通过改变Bcl-2和Bax蛋白增加细胞凋亡，并减少结直肠癌中的血管生成。
Int J Oncol. 2007 Apr;30(4):883-8.

The igf system in carcinogenesis and its implication for cancer therapy.

作者信息

Yang S Y, Winslet M

机构信息

Division of Surgery and Interventional Science, UCL Medical School, University College London, London, U.K.

出版信息

Curr Oncol. 2011 Dec;18(6):301-2. doi: 10.3747/co.v18i6.885.

DOI:10.3747/co.v18i6.885
PMID:22184491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3224032/
Abstract
摘要