Baumann R, de Peyer R, Dederding J P, Bosson R, Loizeau E
Division de gastroentérologie et nutrition, Hôpital cantonal universitaire, Genève.
Schweiz Med Wochenschr. 1990 Sep 8;120(36):1304-7.
40 patients with achalasia underwent pneumatic dilatation. 25 were followed up for a mean duration of 3.96 years. Digestive symptoms disappeared in 32% of cases, were diminished in 40% and remained unchanged in 28%. In 8 patients oesophageal manometry after dilatation showed a significant reduction in lower oesophageal sphincter pressure. The patients showing improvement had a more marked drop in lower oesophageal sphincter pressure, lower residual pressure in the lower oesophageal sphincter measured by wet swallows, and negative pressure in the oesophagus. As complications 3 patients developed oesophageal perforation with one subsequent death, and 3 symptomatic gastro-oesophageal reflux. In view of these results, we regard pneumatic dilatation as the treatment of choice in achalasia.
40例贲门失弛缓症患者接受了气囊扩张治疗。其中25例患者接受了平均3.96年的随访。32%的病例消化症状消失,40%的病例症状减轻,28%的病例症状无变化。8例患者扩张后食管测压显示食管下括约肌压力显著降低。症状改善的患者食管下括约肌压力下降更明显,吞咽湿棉球测量的食管下括约肌残余压力更低,且食管内有负压。作为并发症,3例患者发生食管穿孔,其中1例随后死亡,3例出现有症状的胃食管反流。鉴于这些结果,我们认为气囊扩张是贲门失弛缓症的首选治疗方法。