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高淋巴样增强子结合因子-1表达与慢性淋巴细胞白血病的疾病进展及不良预后相关。

High lymphoid enhancer-binding factor-1 expression is associated with disease progression and poor prognosis in chronic lymphocytic leukemia.

作者信息

Erdfelder Felix, Hertweck Magdalena, Filipovich Alexandra, Uhrmacher Sabrina, Kreuzer Karl-Anton

机构信息

Department I of Internal Medicine, University at Cologne, Germany.

出版信息

Hematol Rep. 2010 Jan 26;2(1):e3. doi: 10.4081/hr.2010.e3. Epub 2010 May 6.

Abstract

We determined lymphoid enhancer-binding factor-1 (LEF1) mRNA expression in 112 chronic lymphocytic leukemia (CLL) samples and assessed correlations with the prognostic markers ZAP70 and CD38, Binet stages, the percentage of lymphocytes in the peripheral blood, and fibromodulin (FMOD) transcripts. The mean LEF1 relative expression ratios (RER) were 53.72 and 37.10 in ZAP70-positive and ZAP70-negative patients, respectively (P=0.004). However, we did not observe a significant difference in LEF1 expression between CD38-positive and CD38-negative patients. Moreover, patients requiring treatment showed a mean LEF1 RER of 85.61 whereas patients in recently diagnosed Binet A stage had a mean of only 22.01 (P<0.001). We also found significant correlations of LEF1 with the percentage of lymphocytes and FMOD expression. Our results suggest that high LEF1 expression is associated with poor prognosis and disease progression. Thus, LEF1 might be involved in the process of disease progression and possibly can serve as a molecular parameter for risk assessment and/or monitoring of CLL.

摘要

我们测定了112例慢性淋巴细胞白血病(CLL)样本中淋巴样增强子结合因子1(LEF1)的mRNA表达,并评估了其与预后标志物ZAP70和CD38、Binet分期、外周血淋巴细胞百分比以及纤调蛋白(FMOD)转录本的相关性。ZAP70阳性和ZAP70阴性患者的LEF1相对表达率(RER)均值分别为53.72和37.10(P = 0.004)。然而,我们未观察到CD38阳性和CD38阴性患者之间LEF1表达有显著差异。此外,需要治疗的患者LEF1 RER均值为85.61,而近期诊断为Binet A期的患者均值仅为22.01(P<0.001)。我们还发现LEF1与淋巴细胞百分比和FMOD表达存在显著相关性。我们的结果表明,LEF1高表达与预后不良和疾病进展相关。因此,LEF1可能参与疾病进展过程,并且可能作为CLL风险评估和/或监测的分子参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe7b/3222268/eac12a40755e/hr-2010-1-e3-g001.jpg

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