Langer R
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139.
Science. 1990 Sep 28;249(4976):1527-33. doi: 10.1126/science.2218494.
Conventional forms of drug administration generally rely on pills, eye drops, ointments, and intravenous solutions. Recently, a number of novel drug delivery approaches have been developed. These approaches include drug modification by chemical means, drug entrapment in small vesicles that are injected into the bloodstream, and drug entrapment within pumps or polymeric materials that are placed in desired bodily compartments (for example, the eye or beneath the skin). These techniques have already led to delivery systems that improve human health, and continued research may revolutionize the way many drugs are delivered.
传统的药物给药形式通常依赖于药丸、眼药水、药膏和静脉注射液。最近,已经开发出了许多新型药物递送方法。这些方法包括通过化学手段对药物进行修饰、将药物包裹在注入血液的小囊泡中,以及将药物包裹在置于身体特定部位(例如眼睛或皮下)的泵或聚合物材料中。这些技术已经带来了改善人类健康的递送系统,持续的研究可能会彻底改变许多药物的递送方式。