Muheyati Maiyier, Wu Guangheng, Li Yilin, Pan Ziting, Chen Yueyue
Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China.
Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, People's Republic of China.
J Nanobiotechnology. 2024 Dec 23;22(1):790. doi: 10.1186/s12951-024-03024-z.
Polymeric biomaterials have important applications in aiding clinical disease treatment, including drug delivery, bioimaging, and tissue engineering. Currently, conventional tumor chemotherapy faces obstacles such as poor solubility/stability, inability to target, and uncontrolled drug release in clinical trials, for which the emergence of supramolecular material therapeutics combining non-covalent interactions with conventional therapies is a very promising candidate. Due to their molecular recognition abilities with a range of biomolecules, cucurbit[n]uril (CB[n]), a type of macrocyclic receptors with robust backbones, hydrophobic cavities, and carbonyl-binding channels, have garnered a lot of attention. Therefore, this paper reviews recent advances in CB[n] material-based supramolecular therapeutics for clinical treatments, including targeted delivery applications and related imaging and sensing systems. This study also covers the distinctive benefits of CB materials for biological applications, as well as the trends and prospects of this interdisciplinary subject, based on numerous state-of-the-art research findings.
高分子生物材料在辅助临床疾病治疗方面具有重要应用，包括药物递送、生物成像和组织工程。目前，传统的肿瘤化疗在临床试验中面临着诸如溶解性/稳定性差、无法靶向以及药物释放不受控制等障碍，而将非共价相互作用与传统疗法相结合的超分子材料疗法的出现是一个非常有前景的候选方案。由于其对一系列生物分子的分子识别能力，葫芦[n]脲（CB[n]），一种具有坚固骨架、疏水腔和羰基结合通道的大环受体，受到了广泛关注。因此，本文综述了基于CB[n]材料的超分子疗法在临床治疗方面的最新进展，包括靶向递送应用以及相关的成像和传感系统。基于众多前沿研究成果，本研究还涵盖了CB材料在生物应用方面的独特优势，以及这一跨学科主题的趋势和前景。
