Bolton C F, Gilbert J J, Girvin J P, Hahn A
Neurology. 1979 Mar;29(3):354-62. doi: 10.1212/wnl.29.3.354.
We correlated the results of biopsy of a muscle nerve, a sensory nerve, and tibialis anterior muscle with electrophysiologic studies in 13 patients with sensorimotor polyneuropathy and 6 patients with normal findings. There were significant correlations between teased fiber changes and conduction abnormalities in both muscle nerves and sensory nerves. The density of large myelinated fibers in the lateral fascicle of the deep peroneal (LFDP) nerve correlated significantly with both the motor unit estimate and compound action potential amplitude of the extensor digitorum brevis (EDB) muscle. Other characteristics of the EDB muscle compound action potential related poorly to teased fiber abnormalities. There was good correlation of needle electrode study of the EDB muscle with teased fiber analysis of the LFDP nerve and with the morphology of the tibialis anterior muscle in 75 percent of the cases, and only minor discrepancies in the remainder. These results emphasize the close relationship between certain structural and electrophysiologic changes in subacute and chronic polyneuropathy.
我们将13例感觉运动性多发性神经病患者和6例检查结果正常的患者的肌肉神经、感觉神经及胫前肌活检结果与电生理研究结果进行了对比。在肌肉神经和感觉神经中， teased纤维改变与传导异常之间存在显著相关性。腓深神经外侧束（LFDP）中大型有髓纤维的密度与趾短伸肌（EDB）的运动单位估计值和复合动作电位幅度均显著相关。EDB肌肉复合动作电位的其他特征与teased纤维异常的相关性较差。在75%的病例中，EDB肌肉的针电极检查结果与LFDP神经的teased纤维分析以及胫前肌的形态学结果具有良好的相关性，其余病例仅有轻微差异。这些结果强调了亚急性和慢性多发性神经病中某些结构和电生理变化之间的密切关系。
