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[不同植入材料向内生长行为及骨黏附的比较研究。一项动物实验]

[Comparative studies on the ingrowth behavior and the bone adhesion of various implant materials. An animal experiment].

作者信息

Eitenmüller J, Schmickal T, David A, Muhr G

机构信息

Chirurgische Universitätsklinik und Poliklinik, Berufsgenossenschaftliche Krankenanstalten, Bergmannsheil Bochum.

出版信息

Unfallchirurg. 1990 Sep;93(9):405-11.

PMID:2218556
Abstract

Each of 36 mongrel dogs received implants of the following six materials: methyl methacrylate, carbon fibre composite, aluminium oxide-ceramic, titanium alloy, pure titanium and hydroxylapatite (HA). Test rods 7 mm in diameter were used to perform a push-out test, and discs with a diameter of 25 mm and a thickness of 5 mm were used for a plane traction test. The animals got a fluorochrome labelling and were harvested 8 weeks after operation. The results of the push-out test were a stability of 3.6 N/mm2 for HA and very low values for all the other materials, while the plane tension test showed a stability of 1.6 N/mm2 for the HA discs and values that were not even measurable for all the other materials. The interface of HA and the bone could not be separated by mechanical forces; usually the bone or the ceramic material fractured beneath the interface, so that the real stability of the interface must be rated very high. Light and fluorescence microscopy revealed a close bone connection for HA and only partial connections for the other materials. HA-coated materials may have a future in orthopaedics surgery.

摘要

36只杂种犬分别植入以下六种材料:甲基丙烯酸甲酯、碳纤维复合材料、氧化铝陶瓷、钛合金、纯钛和羟基磷灰石(HA)。使用直径7毫米的测试棒进行推出试验,使用直径25毫米、厚度5毫米的圆盘进行平面拉伸试验。对动物进行荧光标记,并在术后8周处死取材。推出试验结果显示,HA的稳定性为3.6 N/mm²,其他所有材料的值都非常低;而平面拉伸试验表明,HA圆盘的稳定性为1.6 N/mm²,其他所有材料的值甚至无法测量。HA与骨的界面无法通过机械力分离;通常在界面下方骨或陶瓷材料会发生断裂,因此界面的实际稳定性必须被评定为非常高。光学显微镜和荧光显微镜检查显示,HA与骨连接紧密,其他材料仅部分连接。HA涂层材料在骨科手术中可能具有应用前景。

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