Lions Vision Research and Rehabilitation Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2020, USA.
Curr Opin Neurol. 2012 Feb;25(1):67-75. doi: 10.1097/WCO.0b013e32834f02c3.
This review summarizes the current status of retinal prostheses, recent accomplishments, and major remaining research, engineering, and rehabilitation challenges.
Retinal research, materials and biocompatibility studies, and clinical trials in patients blind from retinitis pigmentosa are representative of an emerging field with considerable promise and sobering challenges. A summary of progress in dozens of laboratories, companies, and clinics around the world is presented through a synopsis of relevant studies, not only to summarize the progress but also to convey the remarkable increase in interest, effort, and outside funding this field has enjoyed.
At present, clinical applications of retinal implant technology are dominated by one or two groups/companies, but the field is wide open for others to take the lead through novel approaches in technology, tissue interfacing, information transfer paradigms, and rehabilitation. Where the field will go in the next few years is almost anybody's guess, but that it will move forward is a certainty.
本文综述了视网膜假体的现状、最新进展以及主要的剩余研究、工程和康复挑战。
视网膜研究、材料和生物相容性研究以及色素性视网膜炎致盲患者的临床试验代表了一个具有巨大潜力和严峻挑战的新兴领域。通过相关研究的摘要，总结了世界各地数十个实验室、公司和诊所的进展，不仅总结了进展，还传达了该领域兴趣、努力和外部资金的显著增加。
目前，视网膜植入技术的临床应用主要由一两个小组/公司主导，但该领域为其他人提供了通过技术、组织界面、信息传输模式和康复方面的新方法来引领潮流的机会。在未来几年，该领域将走向何方几乎是任何人都无法预测的，但可以肯定的是，它将向前发展。
