纳米颗粒的治疗益处：纳米科学在视网膜退行性疾病中的潜在意义。
Therapeutic Benefits from Nanoparticles: The Potential Significance of Nanoscience in Retinal Degenerative Diseases.
作者信息
Rajala Raju V S
机构信息
Departments of Ophthalmology, Physiology and Cell Biology, University of Oklahoma Health Sciences Center, Dean McGee Eye Institute, Oklahoma City, OK 73104, USA.
出版信息
J Mol Biol Ther. 2019;1:44-55.
Several nanotechnology podiums have gained remarkable attention in the area of medical sciences, including diagnostics and treatment. In the past decade, engineered multifunctional nanoparticles have served as drug and gene carriers. The most important aspect of translating nanoparticles from the bench to bedside is safety. These nanoparticles should not elicit any immune response and should not be toxic to humans or the environment. Lipid-based nanoparticles have been shown to be the least toxic for applications, and significant progress has been made in gene and drug delivery employing lipid-based nanoassemblies. Several excellent reviews and reports discuss the general use and application of lipid-based nanoparticles; our review focuses on the application of lipid-based nanoparticles for the treatment of ocular diseases, and recent advances in and updates on their use.
在医学科学领域，包括诊断和治疗方面，几种纳米技术平台已经引起了显著关注。在过去十年中，工程化多功能纳米颗粒已用作药物和基因载体。将纳米颗粒从实验室应用到临床的最重要方面是安全性。这些纳米颗粒不应引发任何免疫反应，且对人类或环境无毒。基于脂质的纳米颗粒已被证明在应用中毒性最小，并且在使用基于脂质的纳米组装体进行基因和药物递送方面已经取得了重大进展。几篇优秀的综述和报告讨论了基于脂质的纳米颗粒的一般用途和应用；我们的综述重点关注基于脂质的纳米颗粒在眼部疾病治疗中的应用，以及它们使用的最新进展和更新情况。
Zotero 插件