Department of Radiological Sciences, St Jude Children's Research Hospital, 332 Danny Thomas Place, Memphis, TN 38105, USA.
Cancer Imaging. 2011 Oct 3;11 Spec No A(1A):S44-7. doi: 10.1102/1470-7330.2011.9008.
Neuroblastoma is the most common extracranial solid malignancy in children. The tumor has variable biological behavior that can be predicted by patient age, genetic features, tumor biology and extent of disease at diagnosis. Factors chosen by various cooperative groups to define risk of treatment failure have been non-uniform. Therefore, historically, it has been difficult to compare outcomes across clinical trials performed around the world. This has hindered the advancement of treatment strategies to improve survival of these patients. The International Neuroblastoma Risk Group (INRG) was established in 2004 to develop a consensus approach to pretreatment risk stratification. The result was the development of the INRG Staging System (INRGSS) which relies on imaging-defined risk factors (IDRFs) that are determined before surgery or other therapy. With the application of the INRGSS the radiologist's role in staging children with neuroblastoma is increased. This review provides an overview of the INRGSS and the IDRFs.
神经母细胞瘤是儿童最常见的颅外实体恶性肿瘤。该肿瘤具有不同的生物学行为，可通过患者年龄、遗传特征、肿瘤生物学和诊断时疾病的范围来预测。各个合作组选择的用于定义治疗失败风险的因素并不统一。因此，从历史上看，很难比较全球开展的临床试验的结果。这阻碍了治疗策略的发展，以提高这些患者的生存率。国际神经母细胞瘤风险组（INRG）于 2004 年成立，旨在制定一种共识方法来进行预处理风险分层。其结果是制定了 INRG 分期系统（INRGSS），该系统依赖于手术或其他治疗前确定的成像定义的风险因素（IDRFs）。应用 INRGSS 后，放射科医生在对神经母细胞瘤患儿进行分期中的作用得到了增强。这篇综述概述了 INRGSS 和 IDRFs。
