Department of Biology, University of Alabama at Birmingham, 175A Campbell Hall, 1300 University Blvd, Birmingham, AL 35294-1170, USA.
J Oncol. 2012;2012:192464. doi: 10.1155/2012/192464. Epub 2011 Dec 7.
The genesis of cancer is often a slow process and the risk of developing cancer increases with age. Altering a diet that includes consumption of beneficial phytochemicals can influence the balance and availability of dietary chemopreventive agents. In chemopreventive approaches, foods containing chemicals that have anticancer properties can be supplemented in diets to prevent precancerous lesions from occurring. This necessitates further understanding of how phytochemicals can potently maintain healthy cells. Fortunately there is a plethora of plant-based phytochemicals although few of them are well studied in terms of their application as cancer chemopreventive and therapeutic agents. In this analysis we will examine phytochemicals that have strong chemopreventive and therapeutic properties in vitro as well as the design and modification of these bioactive compounds for preclinical and clinical applications. The increasing potential of combinational approaches using more than one bioactive dietary compound in chemoprevention or cancer therapy will also be evaluated. Many novel approaches to cancer prevention are on the horizon, several of which are showing great promise in saving lives in a cost-effective manner.
癌症的发生通常是一个缓慢的过程，患癌风险随着年龄的增长而增加。改变包括摄入有益植物化学物质的饮食可以影响膳食化学预防剂的平衡和可用性。在化学预防方法中，可以在饮食中补充含有抗癌特性的化学物质的食物，以防止癌前病变的发生。这需要进一步了解植物化学物质如何能够强有力地维持健康细胞。幸运的是，有大量的植物性植物化学物质，尽管其中很少有被很好地研究作为癌症化学预防和治疗剂的应用。在本分析中，我们将研究在体外具有强大化学预防和治疗特性的植物化学物质，以及这些生物活性化合物的设计和修饰，以用于临床前和临床应用。还将评估使用一种以上生物活性膳食化合物进行化学预防或癌症治疗的联合方法的日益增加的潜力。癌症预防的许多新方法正在出现，其中一些方法在以具有成本效益的方式挽救生命方面显示出巨大的希望。
