Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330 Ankara, Turkey.
Department of Pharmacognosy, Faculty of Pharmacy, Acibadem Mehmet Ali Aydınlar University, 34752 Istanbul, Turkey.
Oxid Med Cell Longev. 2022 Aug 16;2022:6044640. doi: 10.1155/2022/6044640. eCollection 2022.
Among various cancers, breast cancer is the most prevalent type in women throughout the world. Breast cancer treatment is challenging due to complex nature of the etiology of disease. Cell division cycle alterations are often encountered in a variety of cancer types including breast cancer. Common treatments include chemotherapy, surgery, radiotherapy, and hormonal therapy; however, adverse effects and multidrug resistance lead to complications and noncompliance. Accordingly, there is an increasing demand for natural products from medicinal plants and foods. This review summarizes molecular mechanisms of signaling pathways in breast cancer and identifies mechanisms by which natural compounds may exert their efficacy in the treatment of breast cancer.
在各种癌症中，乳腺癌是全世界女性最常见的类型。由于疾病病因的复杂性，乳腺癌的治疗具有挑战性。细胞分裂周期改变在包括乳腺癌在内的多种癌症类型中经常遇到。常见的治疗方法包括化疗、手术、放疗和激素治疗；然而，不良反应和多药耐药性导致并发症和不遵医嘱。因此，对药用植物和食品中的天然产物的需求日益增加。本综述总结了乳腺癌中信号通路的分子机制，并确定了天然化合物可能发挥其治疗乳腺癌功效的机制。
