Chetty R
Department of Anatomical Pathology, University of Cape Town and Groote Schuur Hospital.
S Afr J Surg. 1990 Sep;28(3):95-7.
Two medullary carcinomas of the thyroid (MCTs) composed entirely of Hürthle (oncocytic or oxyphilic) cells and containing follicular structures are described. Immunocytochemical analysis showed these tumours to be calcitonin-, carcino-embryonic antigen- and neuron-specific enolase-positive. The essence of this communication is twofold. Firstly, it highlights and draws attention to this unusual variant of MCT, which may be encountered at frozen section and misdiagnosed as a Hürthle cell tumour of follicular cell origin. Secondly, it undertakes a concise overview of the immunocytochemistry of Hürthle cell thyroid neoplasms and MCT.
本文描述了两例甲状腺髓样癌（MCT），其完全由许特莱（嗜酸性或嗜氧性）细胞组成，并含有滤泡结构。免疫细胞化学分析显示，这些肿瘤降钙素、癌胚抗原和神经元特异性烯醇化酶呈阳性。本文的要点有两个。首先，它强调并提请注意这种不寻常的MCT变体，在冰冻切片时可能会遇到，并被误诊为滤泡细胞来源的许特莱细胞瘤。其次，它对许特莱细胞甲状腺肿瘤和MCT的免疫细胞化学进行了简要概述。
