Bilgin Ilgül, Bozdağ Kübra Eren, Uysal Seçil, Ermete Murat
Atatürk Education and Research Hospital, Department of Dermatology, Izmir, Turkey.
J Dermatol Case Rep. 2011 Sep 21;5(3):50-2. doi: 10.3315/jdcr.2011.1075.
Progressive symmetrical erythrokeratoderma is characterized by well-demarcated, symmetrically distributed, erythtematous and hyperkeratotic plaques. Treatment options are topical retinoids, emollients, keratolytics and topical corticosteroids with limited or no success. Oral retinoids have been shown to be successful in some cases, but recurrence is to be expected on cessation of therapy. Topical calcipotriol is an established mode of treatment for psoriasis and also reported to be effective in many hyperkeratotic skin diseases.
A 20-year-old female patient presented with reddish-brown lesions in her axillae, groins, submammary regions and on the eyelids. Clinical and histological findings were consistent with the diagnosis of progressive symmetrical erythrokeratoderma. She had noted that her lesions did not improve with topically applied steroids and emollients. We recommended our patient to use topical calcipotriol and observed a remarkable improvement within two weeks.
When compared with the other treatment modalities, topical calcipotriol is a safe and effective drug with minimal side effects and it would be a good alternative.
进行性对称性红斑角皮症的特征为界限清楚、对称分布的红斑及角化过度斑块。治疗方法包括外用维甲酸、润肤剂、角质剥脱剂和外用糖皮质激素,但效果有限或无效。口服维甲酸在某些病例中已显示有效,但停药后易复发。外用卡泊三醇是治疗银屑病的一种既定方法,也有报道称对许多角化过度性皮肤病有效。
一名20岁女性患者腋窝、腹股沟、乳房下区域及眼睑出现红棕色皮损。临床和组织学检查结果符合进行性对称性红斑角皮症的诊断。她注意到外用类固醇和润肤剂并不能改善皮损。我们建议该患者使用外用卡泊三醇,两周内观察到明显改善。
与其他治疗方式相比,外用卡泊三醇是一种安全有效的药物,副作用极小,是一个很好的选择。