Attia Abdalla, Seleit Iman, El Badawy Nafeesa, Bakry Ola, Yassien Hossam
Department of Dermatology, Andrology and S.T.Ds, 1st floor, Menoufiya University Hospital, Faculty of Medicine, Faculty of Medicine Street., Shibeen El Koom, 32817 Menoufiya Governorate, Egypt.
J Dermatol Case Rep. 2011 Sep 21;5(3):53-5. doi: 10.3315/jdcr.2011.1076.
Generalized eruptive histiocytoma is a rare form of non Langerhan's cell histiocytosis. The disease occurs mainly in adults and its etiology is still unknown. We describe a case of 48-year-old female with multiple, firm, hemispherical, redish brown papules. Lesions were distributed on the face, upper limbs and trunk. Patient's general examination and routine laboratory investigations were normal. Excisional biopsy was taken from one representative lesion. Histopathological examination revealed diffuse dermal histiocytic infiltration that was suggestive of generalized eruptive histiocytoma. Confirmatory immunohistochemical staining for CD68 antibody was done and revealed positive results. Based on clinical and histopathological criteria the diagnosis of generalized eruptive histiocytoma was established.In conclusion, we present a rare case of generalized eruptive histiocytoma which is an uncommon form of non Langerhan's cell histiocytosis. The disease does not require treatment since it is a self-healing disease.
泛发性发疹性组织细胞瘤是一种罕见的非朗格汉斯细胞组织细胞增生症。该疾病主要发生于成年人,其病因尚不清楚。我们描述了一例48岁女性患者,其有多个坚实的、半球形的红棕色丘疹。皮损分布于面部、上肢和躯干。患者的全身检查和常规实验室检查均正常。从一个代表性皮损处进行了切除活检。组织病理学检查显示真皮弥漫性组织细胞浸润,提示泛发性发疹性组织细胞瘤。进行了CD68抗体的确诊性免疫组化染色,结果呈阳性。根据临床和组织病理学标准,确诊为泛发性发疹性组织细胞瘤。总之,我们报告了一例罕见的泛发性发疹性组织细胞瘤病例,它是一种不常见的非朗格汉斯细胞组织细胞增生症。由于该疾病是一种自愈性疾病,无需治疗。