Bellivier Frank, Etain Bruno, Malafosse Alain, Henry Chantal, Kahn Jean-Pierre, Elgrabli-Wajsbrot Orly, Jamain Stéphane, Azorin Jean-Michel, Frank Ellen, Scott Jan, Grochocinski Victoria, Kupfer David J, Golmard Jean-Louis, Leboyer Marion
AP-HP, Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie , Créteil, F-94000 , France.
World J Biol Psychiatry. 2014 Jul;15(5):369-76. doi: 10.3109/15622975.2011.639801. Epub 2011 Dec 21.
To test for differences in reported age at onset (AAO) of bipolar I affective disorder in clinical samples drawn from Europe and the USA.
Admixture analysis was used to identify the model best fitting the observed AAO distributions of two large samples of bipolar I patients from Europe and USA (n = 3616 and n = 2275, respectively). Theoretical AAO functions were compared between the two samples.
The model best fitting the observed distribution of AAO in both samples was a mixture of three Gaussian distributions. The theoretical AAO functions of bipolar I disorder differed significantly between the European and USA populations, with further analyses indicating that (i) the proportion of patients belonging to the early-onset subgroup was higher in the USA sample (63 vs. 25%) and (ii) mean age at onset (±SD) in the early-onset subgroup was lower for the USA sample (14.5 ± 4.9 vs. 19 ± 2.7 years).
The models best describing the reported AAO distributions of European and USA bipolar I patients were remarkably stable. The intermediate- and late-onset subgroups had similar characteristics in the two samples. However, the theoretical AAO function differed significantly between the USA and European samples due to the higher proportion of patients in the early-onset subgroup and the lower mean age-at-onset in the USA sample.
检测从欧洲和美国抽取的临床样本中，双相I型情感障碍报告的发病年龄（AAO）是否存在差异。
采用混合分析来确定最适合两个来自欧洲和美国的双相I型患者大样本（分别为n = 3616和n = 2275）观察到的AAO分布的模型。比较两个样本之间的理论AAO函数。
最适合两个样本中观察到的AAO分布的模型是三个高斯分布的混合。欧洲和美国人群中双相I型障碍的理论AAO函数存在显著差异，进一步分析表明：（i）美国样本中属于早发性亚组的患者比例更高（63%对25%）；（ii）美国样本早发性亚组的平均发病年龄（±标准差）更低（14.5±4.9岁对19±2.7岁）。
最能描述欧洲和美国双相I型患者报告的AAO分布的模型非常稳定。两个样本中中发性和晚发性亚组具有相似的特征。然而，由于美国样本中早发性亚组患者比例更高且平均发病年龄更低，美国和欧洲样本之间的理论AAO函数存在显著差异。
