The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia.
Obes Rev. 2012 May;13(5):469-79. doi: 10.1111/j.1467-789X.2011.00969.x. Epub 2011 Dec 21.
Weight loss is a recognized alarm symptom for organic gastrointestinal (GI) disease, yet the association between obesity and specific GI symptoms remains poorly described. A meta-analysis was conducted to determine which GI symptoms predominate among obese individuals. A search of the literature using the databases MEDLINE, EMBASE PubMed and Current Contents (1950 - November 2011) was conducted. All studies assessing GI symptoms and increasing body mass index (BMI)/obesity were included. English and non-English articles were searched. A random effect model of the studies was undertaken. Overall, significant associations between GI symptoms and increasing BMI were found for upper abdominal pain (odds ratio [OR] = 2.65, 95% confidence interval [CI]: 1.23-5.72), gastroesophageal reflux (OR = 1.89, 95% CI: 1.70-2.09), diarrhoea (OR = 1.45, 95% CI: 1.26-1.64), chest pain/heartburn (OR = 1.74, 95% CI: 1.49-2.04), vomiting (OR = 1.76, 95% CI: 1.28-2.41), retching (OR = 1.33, 95% CI: 1.01-1.74) and incomplete evacuation (OR = 1.32, 95% CI: 1.03-1.71). However, no significant associations were found for all abdominal pain, lower abdominal pain, bloating, constipation/hard stools, fecal incontinence, nausea and anal blockage. Several key GI symptoms are associated with increasing BMI and obesity. In addition, there were a number of other GI symptoms that had no relationship with obesity. A greater knowledge of the GI symptoms associated with obesity along with the physiology will be important in the clinical management of these patients.
体重减轻是公认的器质性胃肠道（GI）疾病的报警症状，然而肥胖与特定 GI 症状之间的关联仍描述不足。进行了一项荟萃分析，以确定肥胖人群中哪些 GI 症状更为常见。使用 MEDLINE、EMBASE、PubMed 和 Current Contents（1950 年至 2011 年 11 月）数据库对文献进行了检索。所有评估 GI 症状和体重指数（BMI）/肥胖增加的研究均被纳入。检索了英文和非英文文章。对研究进行了随机效应模型分析。总体而言，上腹痛（OR = 2.65，95%置信区间 [CI]：1.23-5.72）、胃食管反流（OR = 1.89，95% CI：1.70-2.09）、腹泻（OR = 1.45，95% CI：1.26-1.64）、胸痛/烧心（OR = 1.74，95% CI：1.49-2.04）、呕吐（OR = 1.76，95% CI：1.28-2.41）、干呕（OR = 1.33，95% CI：1.01-1.74）和不完全排空（OR = 1.32，95% CI：1.03-1.71）与 BMI 增加之间存在显著关联。然而，所有腹痛、下腹痛、腹胀、便秘/硬便、粪便失禁、恶心和肛门阻塞与肥胖之间均无显著关联。一些关键的 GI 症状与 BMI 增加和肥胖有关。此外，还有一些其他的 GI 症状与肥胖无关。了解与肥胖相关的 GI 症状以及相关生理学知识对于这些患者的临床管理非常重要。
