Talley Nicholas J, Howell Stuart, Poulton Richie
Department of Medicine, University of Sydney, Australia.
Am J Gastroenterol. 2004 Sep;99(9):1807-14. doi: 10.1111/j.1572-0241.2004.30388.x.
An unexplained epidemic of obesity is occurring but the relationship between obesity and gastrointestinal (GI) tract function is unclear. We aimed to evaluate the association between body mass index (BMI) and specific GI symptoms.
A birth cohort in Dunedin, New Zealand, aged 26 yr (n = 980, 94% of total original sample) was evaluated using a validated GI symptom questionnaire. Categories of GI symptom complexes were defined a priori. The association of reported GI symptoms with BMI (kg/m(2)) was assessed adjusting for gender.
The prevalence of obesity (BMI > or = 30 kg/m(2)) was 12%; 30% were overweight. There was a significant univariate positive association between increased BMI and diarrhea (>3 stools/day, loose stools, or urgency); the sex adjusted odds ratio for obese versus normal weight was 1.8 (95% CI 1.1, 2.9; p= 0.02). Abdominal pain associated with nausea or vomiting was positively associated with increased BMI (OR 2.0, 95% CI 1.0, 2.9; p= 0.04). Being overweight was negatively associated with abdominal pain and constipation (OR 0.4, 95% CI 0.2, 0.9; p= 0.02). Irritable bowel syndrome and reflux symptoms were not significantly associated with increased BMI. Waist-to-hip ratios were not significantly associated with GI symptoms. No study members were taking antiobesity medications. Hemoglobin A1c levels were not associated with any of the GI symptoms.
In a general population sample of young adults, increasing BMI was associated with diarrhea and abdominal pain with nausea/vomiting.
肥胖症的流行原因不明，但肥胖与胃肠道（GI）功能之间的关系尚不清楚。我们旨在评估体重指数（BMI）与特定胃肠道症状之间的关联。
使用经过验证的胃肠道症状问卷对新西兰达尼丁一个26岁的出生队列（n = 980，占原始样本总数的94%）进行评估。预先定义了胃肠道症状复合体的类别。在对性别进行校正后，评估所报告的胃肠道症状与BMI（kg/m²）之间的关联。
肥胖（BMI≥30 kg/m²）的患病率为12%；30%的人超重。BMI升高与腹泻（每天排便>3次、大便松散或有便急感）之间存在显著的单变量正相关；肥胖与正常体重者经性别校正后的优势比为1.8（95%CI 1.1, 2.9；p = 0.02）。与恶心或呕吐相关的腹痛与BMI升高呈正相关（OR 2.0，95%CI 1.0, 2.9；p = 0.04）。超重与腹痛和便秘呈负相关（OR 0.4，95%CI 0.2, 0.9；p = 0.02）。肠易激综合征和反流症状与BMI升高无显著关联。腰臀比与胃肠道症状无显著关联。没有研究对象正在服用减肥药。糖化血红蛋白水平与任何胃肠道症状均无关联。
在年轻成年人的一般人群样本中，BMI升高与腹泻以及伴有恶心/呕吐的腹痛相关。
