Laboratory of Veterinary Microbiology, Nippon Veterinary and Life Science University 1-7-1, Kyonan-cho, Musashino, Tokyo, 180-8602, Japan.
Microbiol Immunol. 2012 Feb;56(2):123-7. doi: 10.1111/j.1348-0421.2011.00416.x.
Seventy-three Pseudomonas aeruginosa isolates were collected from dogs and cats in Japan to investigate antimicrobial susceptibility and resistance mechanisms to anti-pseudomonal agents. Resistance rates against orbifloxacin, enrofloxacin, ciprofloxacin, cefotaxime, aztreonam and gentamicin were 34.2, 31.5, 20.5, 17.8, 12.3 and 4.1%, respectively. The degree of resistance to cefotaxime, orbifloxacin, and enrofloxacin was greatly affected by efflux pump inhibitors, indicating overexpression of efflux pump contributes to these resistances. Notably, orbifloxacin and enrofloxacin resistance was observed even in isolates without mutations in the target sites. This is the first report on cephalosporin- and fluoroquinolone-resistant isolates of P. aeruginosa from Japanese companion animals.
从日本的犬猫中收集了 73 株铜绿假单胞菌，以调查其对抗假单胞菌药物的药敏性和耐药机制。对氧氟沙星、恩诺沙星、环丙沙星、头孢噻肟、氨曲南和庆大霉素的耐药率分别为 34.2%、31.5%、20.5%、17.8%、12.3%和 4.1%。头孢噻肟、氧氟沙星和恩诺沙星的耐药程度受外排泵抑制剂的显著影响，表明外排泵的过度表达导致了这些耐药性。值得注意的是，即使在靶位无突变的分离株中也观察到了氧氟沙星和恩诺沙星的耐药性。这是首次报道日本伴侣动物中出现头孢菌素和氟喹诺酮类耐药的铜绿假单胞菌。
