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从健康儿童粪便中分离出的植物乳杆菌 CECT7315 和 CECT7316 的益生菌特性。

Probiotic properties of Lactobacillus plantarum CECT 7315 and CECT 7316 isolated from faeces of healthy children.

机构信息

AB-BIOTICS SA, Cerdanyola del Vallès, Barcelona, Spain.

出版信息

Lett Appl Microbiol. 2012 Mar;54(3):240-6. doi: 10.1111/j.1472-765X.2011.03199.x.

Abstract

AIMS

Not all lactic acid bacteria possess the ability to confer health benefits for the host. Thus, it becomes necessary to screen and characterize numerous strains to obtain ideal probiotics. Here, two Lactobacillus plantarum strains (CECT 7315 and CECT 7316) were isolated and characterized.

METHODS AND RESULTS

In vitro and in vivo tests were carried out for demonstrating the abilities as probiotics of CECT 7315/CECT 7316 Lact. plantarum strains. Both strains showed high ability to survive at gastro-intestinal tract conditions and to adhere to intestinal epithelial cells, as well as great inhibitory activity against a wide range of enteropathogens and ability to induce the production of anti-inflammatory cytokine IL-10.

CONCLUSIONS

Lactobacillus plantarum CECT 7315/CECT 7316 because of their potential probiotic properties could be excellent candidates for being tested in clinical trials aimed to demonstrate beneficial effects on human health.

SIGNIFICANCE AND IMPACT OF THE STUDY

Probiotics are live micro-organisms that confer a health benefit for the host. However, not all the lactic acid bacteria possess the ability to confer health benefits for the host. In this study, two Lact. plantarum strains (CECT 7315 and CECT 7316) were isolated and characterized to demonstrate their excellent qualities as potential probiotic strains.

摘要

目的

并非所有乳酸菌都具有为宿主带来健康益处的能力。因此,有必要筛选和鉴定大量菌株以获得理想的益生菌。在这里,我们分离和鉴定了两株植物乳杆菌(CECT7315 和 CECT7316)。

方法和结果

进行了体外和体内试验,以证明 CECT7315/CECT7316 植物乳杆菌菌株作为益生菌的能力。这两种菌株均显示出在胃肠道条件下存活和黏附于肠上皮细胞的高能力,以及对广泛的肠道病原体的强大抑制活性和诱导抗炎细胞因子 IL-10 产生的能力。

结论

由于潜在的益生菌特性,植物乳杆菌 CECT7315/CECT7316 可以成为临床试验的优秀候选者,旨在证明对人类健康的有益作用。

研究的意义和影响

益生菌是为宿主带来健康益处的活菌。然而,并非所有的乳酸菌都具有为宿主带来健康益处的能力。在这项研究中,我们分离和鉴定了两株植物乳杆菌(CECT7315 和 CECT7316),以证明它们作为潜在益生菌菌株的优良特性。

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