Department of Virology, Parasitology and Immunology, Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium.
Trans R Soc Trop Med Hyg. 2012 Feb;106(2):128-30. doi: 10.1016/j.trstmh.2011.09.007. Epub 2011 Dec 19.
There is considerable variation in the efficacy of single-dose albendazole (400mg) against Trichuris trichiura across human trials. Factors contributing to this variation have not yet been identified. We assessed the impact of mean baseline faecal egg counts (FEC) on the efficacy of single-dose albendazole against T. trichiura in five previously conducted trials. Our results suggest that efficacy measured by reduction in mean FECs decreased significantly (p<0.0001) when mean baseline FECs increased, highlighting that this parameter should be considered as an important confounding factor for drug efficacy.
在针对鞭虫的单剂量阿苯达唑（400mg）疗效的人体试验中，存在相当大的差异。导致这种差异的因素尚未确定。我们评估了平均基线粪便卵计数（FEC）对五种先前进行的试验中单剂量阿苯达唑治疗鞭虫的疗效的影响。我们的结果表明，当平均基线 FEC 增加时，以平均 FEC 减少衡量的疗效显著下降（p<0.0001），这突出表明该参数应被视为药物疗效的一个重要混杂因素。
