不同阿苯达唑和甲苯达唑方案治疗埃塞俄比亚吉姆马镇重度鞭虫感染的疗效比较。
Efficacy of different albendazole and mebendazole regimens against heavy-intensity Trichuris trichiura infections in school children, Jimma Town, Ethiopia.
机构信息
Department of Medical Laboratory Sciences and Pathology, College of Public health and Medical Sciences, Jimma University, Ethiopia.
出版信息
Pathog Glob Health. 2013 Jun;107(4):207-9. doi: 10.1179/2047773213Y.0000000092.
Abstract
Recent studies have shown that the efficacy of benzimidazole drugs is influenced by the intensity of trichuriasis. Therefore, the objective of this study was to determine the efficacy of albendazole (ALB) and mebendazole (MBZ) administered randomly for 1 (ALB×1 and MBZ×1) or 2 days (ALB×2 and MBZ×2) to 385 school children with heavy-intensity trichuriasis (mean faecal egg counts (FEC) >1000 eggs per gram of stool (epg)) in Jimma Town, Ethiopia. The efficacies (95% confidence intervals) by means of reduction in faecal egg counts (FECs) were 29·3% (-9·9-56·2), 60·0% (48·5-70·9), 73·5% (64·2-81·3), and 87·1% (81·4-91·2) for ALB×1, MBZ×1, ALB×2, and MBZ×2, respectively. These observations highlight that assessment of the anthelmintic efficacy of existing or new compounds against Trichuris trichiura should be assessed under varying levels of infection intensity.
摘要
最近的研究表明，苯并咪唑类药物的疗效受到鞭虫感染强度的影响。因此，本研究的目的是确定阿苯达唑（ALB）和甲苯达唑（MBZ）在埃塞俄比亚 Jimma 镇随机给予 1 天（ALB×1 和 MBZ×1）或 2 天（ALB×2 和 MBZ×2）治疗 385 名重度鞭虫感染（粪便虫卵计数（FEC）>1000 个/克粪便（epg））的学龄儿童的疗效。通过减少粪便虫卵计数（FEC）的疗效分别为 29.3%（-9.9-56.2）、60.0%（48.5-70.9）、73.5%（64.2-81.3）和 87.1%（81.4-91.2），用于 ALB×1、MBZ×1、ALB×2 和 MBZ×2。这些观察结果强调，应对现有或新化合物针对鞭虫的驱虫疗效进行评估，应根据感染强度的不同进行评估。
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