Riabov S I, Stavskaia V V
Ter Arkh. 1990;62(6):27-34.
In 520 patients followed up for 4 to 20 years a study was made of the relationship between the actual survival time and the morphological and clinical characteristics of chronic glomerulonephritis. A well-defined parallelism was established between the rate of disease progress and the rate of exacerbations as was an unfavorable prognostic importance of marked tubulointerstitial lesions and glomerular sclerosis, which was more manifest in frequent relapses. Considerable differences in the survival of patients with hypertension or associated hypertension and the nephrotic syndrome with varying process activity do not provide evidence in favour of their direct influence on the rate of the disease progress. As far as certain morphological patterns of glomerulonephritis are concerned, the prognosis is different because of specific clinical manifestations and anatomic alterations common to each disease pattern.
在对520例患者进行了4至20年的随访后，对慢性肾小球肾炎的实际生存时间与形态学和临床特征之间的关系进行了研究。在疾病进展速度和病情加重速度之间建立了明确的平行关系，同时也确定了明显的肾小管间质病变和肾小球硬化具有不良的预后意义，这在频繁复发时更为明显。高血压或伴发高血压以及肾病综合征且病情活动程度不同的患者在生存方面存在显著差异，但这并不支持它们对疾病进展速度有直接影响。就某些肾小球肾炎的形态学模式而言，由于每种疾病模式所共有的特定临床表现和解剖学改变，其预后有所不同。
