Tribeč 病毒和克麦罗沃病毒的遗传特征，两种蜱传的人类致病性呼肠孤病毒。
Genetic characterization of Tribeč virus and Kemerovo virus, two tick-transmitted human-pathogenic Orbiviruses.
机构信息
Department of Virology, University Medical Center Göttingen, Kreuzbergring 57, D-37075 Göttingen, Germany.
出版信息
Virology. 2012 Feb 5;423(1):68-76. doi: 10.1016/j.virol.2011.11.020. Epub 2011 Dec 20.
We determined the complete genome sequences of Tribeč virus (TRBV) and Kemerovo virus (KEMV), two tick-transmitted Orbiviruses that can cause diseases of the central nervous system and that are currently classified into the Great Island virus serogroup. VP2 proteins of TRBV and KEMV show very low sequence similarity to the homologous VP4 protein of tick-transmitted Great Island virus (GIV). The new sequence data support previous serological classification of these Orbiviruses into the Kemerovo serogroup, which is different from the Great Island virus serogroup. Genome segment 9 of TRBV and KEMV encodes several overlapping ORF's in the +1 reading frame relative to VP6(Hel). A co-phylogenetic analysis indicates a host switch from insect-borne Orbiviruses toward Ixodes species, which is in disagreement with previously published data.
我们确定了 Tribeč 病毒 (TRBV) 和 Kemerovo 病毒 (KEMV) 的完整基因组序列，这两种 tick-transmitted Orbiviruses 可引起中枢神经系统疾病，目前被归类为 Great Island 病毒血清群。TRBV 和 KEMV 的 VP2 蛋白与 tick-transmitted Great Island 病毒 (GIV) 的同源 VP4 蛋白的序列相似性非常低。新的序列数据支持这些 Orbiviruses 先前的血清学分类归入 Kemerovo 血清群，与 Great Island 病毒血清群不同。TRBV 和 KEMV 的基因组片段 9 在相对于 VP6(Hel)的 +1 读码框中编码几个重叠的 ORF。共进化分析表明，宿主从昆虫传播的 Orbiviruses 向Ixodes 物种发生了转变，这与先前发表的数据不一致。
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