Murayama Ryouta, Nagata Naoki, Honda Shinsaku, Fujii Mio, Sawatsubashi Takahiro, Shinohara Ikuyo, Kuroda Hiroaki, Sako Tatsuhiko, Sakamoto Yoshihiko, Sanefuji Hayato
Dept. of Surgery, Kitakyushu General Hospital.
Gan To Kagaku Ryoho. 2011 Dec;38(13):2655-7.
The patient is a 62-year-old female who underwent a right hemicolectomy for type-2 ascending colon cancer (moderately-differentiated adenocarcinoma, ss, n0, H0, P0, M0, stage II). Six months after the surgery, a solitary metastatic focus was expressed in the liver S3. Because schizophrenia was present concurrently, tegafur and uracil/folinate (UFT/Leucovorin) treatment was selected and performed for 3 months. Because the tumor shrank afterward, a partial hepatectomy was performed to obtain a curative resection. In a pathological examination of the resected focus, cicatricial/necrotic findings were observed, but no cancer cells were observed; hence, it was determined to be a pathological complete response (CR). In regard to chemotherapy for distant metastasis of colorectal cancer, many molecular-targeted agents are being introduced, thus resulting in more treatment options; however, depending on the patient's background, UFT/LV treatment can be an effective treatment option.
该患者为62岁女性，因升结肠2型癌（中分化腺癌，ss，n0，H0，P0，M0，II期）接受了右半结肠切除术。术后6个月，肝脏S3出现一个孤立性转移灶。由于同时患有精神分裂症，选择替加氟尿嘧啶/亚叶酸钙（UFT/甲酰四氢叶酸）治疗并进行了3个月。此后由于肿瘤缩小，进行了部分肝切除术以实现根治性切除。在对切除病灶的病理检查中，观察到瘢痕/坏死表现，但未观察到癌细胞；因此，确定为病理完全缓解（CR）。关于结直肠癌远处转移的化疗，许多分子靶向药物正在被引入，从而产生了更多的治疗选择；然而，根据患者的背景情况，UFT/LV治疗可能是一种有效的治疗选择。
