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[肾淋巴管在肾病综合征发病机制中的作用]

[The role of the kidney lymphatic capillaries in the pathogenesis of the nephrotic syndrome].

作者信息

Shishkin A N, Variasina T N, Shulutko B I

出版信息

Ter Arkh. 1990;62(6):53-5.

PMID:2218928
Abstract

As many as 16 patients with nephrotic syndrome (NS) of varying etiology and 10 patients without the NS were examined for ultrastructure of lymph capillaries of the kidney. Many-staged changes, from regenerative to destructive ones, associated with proteinuria growth and formation of the NS were revealed in lymph capillaries of the kidney. Patients with the NS of long standing manifested irreversible destructive processes--destruction of the capillary walls, karyopyknosis and cytoplasm coagulation. Microcirculatory disorders may be regarded as one of the mechanisms implicated in nephropathy progress.

摘要

对多达16例病因各异的肾病综合征(NS)患者和10例无肾病综合征的患者进行了肾淋巴管超微结构检查。在肾淋巴管中发现了与蛋白尿增加和肾病综合征形成相关的从再生到破坏的多阶段变化。病程较长的肾病综合征患者表现出不可逆的破坏过程——毛细血管壁破坏、核固缩和细胞质凝固。微循环障碍可能被视为肾病进展的机制之一。

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