Department of Public Health, China Medical University, Taichung 404, Taiwan.
Chemosphere. 2012 Mar;87(1):26-30. doi: 10.1016/j.chemosphere.2011.11.048. Epub 2011 Dec 19.
A mass screening of lung function associated with air pollutants for children is limited. This study assessed the association between air pollutants exposure and the lung function of junior high school students in a mass screening program in Taipei city, Taiwan. Among 10,396 students with completed asthma screening questionnaires and anthropometric measures, 2919 students aged 12-16 received the spirometry test. Forced vital capacity (FVC) and forced expiratory flow in 1s (FEV(1)) in association with daily ambient concentrations of particulate matter with diameter of 10 μm or less (PM(10)), sulfur dioxide (SO(2)), carbon monoxide (CO), nitrogen dioxide (NO(2)), and ozone (O(3)) were assessed by regression models controlling for the age, gender, height, weight, student living districts, rainfall and temperature. FVC, had a significant negative association with short-term exposure to O(3) and PM(10) measured on the day of spirometry testing. FVC values also were reversely associated with means of SO(2), O(3), NO(2), PM(10) and CO exposed 1 d earlier. An increase of 1-ppm CO was associated with the reduction in FVC for 69.8 mL (95% CI: -115, -24.4 mL) or in FEV(1) for 73.7 mL (95% CI: -118, -29.7 mL). An increase in SO(2) for 1 ppb was associated with the reductions in FVC and FEV(1) for 12.9 mL (95% CI: -20.7, -5.09 mL) and 11.7 mL (95% CI: -19.3, -4.16 mL), respectively. In conclusion, the short-term exposure to O(3) and PM(10) was associated with reducing FVC and FEV(1). CO and SO(2) exposure had a strong 1-d lag effect on FVC and FEV(1).
一项针对儿童肺部功能与空气污染物相关性的大规模筛查工作受到限制。本研究旨在评估台湾台北市大规模筛查项目中，初中生在空气污染物暴露下的肺部功能与哮喘之间的关系。在完成哮喘筛查问卷和人体测量的 10396 名学生中，有 2919 名 12-16 岁的学生接受了肺活量测试。通过回归模型，控制年龄、性别、身高、体重、学生居住区域、降雨量和温度等因素，评估了用力肺活量（FVC）和 1 秒用力呼气量（FEV1）与每日环境中直径 10 μm 或以下的颗粒物（PM10）、二氧化硫（SO2）、一氧化碳（CO）、二氧化氮（NO2）和臭氧（O3）浓度之间的关系。FVC 与测试当天短期接触 O3 和 PM10 呈显著负相关。FVC 值也与前一天暴露的 SO2、O3、NO2、PM10 和 CO 的平均值呈反比。CO 浓度每增加 1ppm，FVC 降低 69.8ml（95%CI：-115，-24.4ml），FEV1 降低 73.7ml（95%CI：-118，-29.7ml）。SO2 浓度每增加 1ppb，FVC 和 FEV1 分别降低 12.9ml（95%CI：-20.7，-5.09ml）和 11.7ml（95%CI：-19.3，-4.16ml）。综上所述，短期暴露于 O3 和 PM10 与 FVC 和 FEV1 降低有关。CO 和 SO2 暴露对 FVC 和 FEV1 具有很强的 1 天滞后效应。
