Soonchunhyang Medical Research Institute, College of Medicine, Soonchunhyang University, Chunan, 330-090, Republic of Korea.
Mol Biol Rep. 2012 May;39(5):5425-32. doi: 10.1007/s11033-011-1342-9. Epub 2011 Dec 22.
Abundant evidence supports the hypothesis that inflammation plays an important role in the development of coronary artery disease (CAD). In this study, we investigated whether genetic polymorphisms of the Interferon gamma (IFNG) gene were associated with the number of diseased vessels in CAD patients in the Korean population. To observe the association between the IFNG gene and the number of diseased vessels, we genotyped 635 CAD patients for a single nucleotide polymorphism (SNP, rs2430561) and a microsatellite (CA(n) repeats, rs3138557) located in the first intron of the IFNG gene using the direct sequencing and gene scan method. The number of microsatellites was increased in the one- and two-vessel disease groups. A combined analysis of the genotype of rs2430561 and the number of microsatellites revealed that the number of diseased vessels was associated with CA(12)-TT and CA(13)-TT. Our results suggest that the IFNG gene may be one of the factors determining the extent of CAD in the Korean population. Larger collaborative studies are needed to confirm these results.
大量证据支持这样一种假说，即炎症在冠状动脉疾病 (CAD) 的发展中起着重要作用。在这项研究中，我们调查了干扰素 γ (IFNG) 基因的遗传多态性是否与韩国人群 CAD 患者病变血管的数量有关。为了观察 IFNG 基因与病变血管数量之间的关联，我们使用直接测序和基因扫描方法对 635 名 CAD 患者进行了单核苷酸多态性 (SNP，rs2430561) 和位于 IFNG 基因第一内含子中的微卫星 (CA(n) 重复，rs3138557) 的基因分型。微卫星的数量在单支和两支病变血管组中增加。rs2430561 基因型和微卫星数量的联合分析表明，病变血管的数量与 CA(12)-TT 和 CA(13)-TT 相关。我们的结果表明，IFNG 基因可能是决定韩国人群 CAD 严重程度的因素之一。需要更大规模的合作研究来证实这些结果。
