铜（I）催化的 5-芳基吲唑并[3,2-b]喹唑啉-7(5H)-酮的Ullmann 型反应合成。

Copper(I)-catalyzed synthesis of 5-arylindazolo[3,2-b]quinazolin-7(5H)-one via Ullmann-type reaction.

机构信息

School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou Jiangsu 221116, PR China.

出版信息

J Org Chem. 2013 Jun 7;78(11):5700-4. doi: 10.1021/jo400420b. Epub 2013 May 23.

DOI:10.1021/jo400420b

PMID:23675901

Abstract

The treatment of 2-amino-N'-arylbenzohydrazide and o-halogenated benzaldehyde in the presence of CuBr and Cs2CO3 gave 5-arylindazolo[3,2-b]quinazolin-7(5H)-one in high yields. This procedure contains an Ullmann-type reaction and provides an efficient method to construct fused tetracyclic heterocycles.

摘要

在 CuBr 和 Cs2CO3 的存在下，2-氨基-N'-芳基苯甲酰肼和邻卤代苯甲醛反应得到高收率的 5-芳基吲唑并[3,2-b]喹唑啉-7(5H)-酮。该过程包含 Ullmann 型反应，提供了一种构建稠合四环杂环的有效方法。