Kato Hideharu, Nomura Jouji, Matsumura Yoshihiko, Yanase Shigeaki, Miyahara Kaori, Matsuura Rina, Tagawa Toshiro
J Maxillofac Oral Surg. 2010 Jun;9(2):213-7. doi: 10.1007/s12663-010-0054-3. Epub 2010 Sep 22.
Spindle Cell Carcinoma (SPCC) is a relatively rare tumour that is classified as a subtype of squamous cell carcinoma (SCC). Histologically, SPCC is composed of a SCC region and epithelium-derived spindle cells with mesenchymal differentiation. We encountered an interesting case of multiple cancer including SPCC. A histopathologically atypical papillary lesion was found 13 years before our initial examination. Multiple verrucous leukoplakia later developed in the oral mucosa, for which an oral vitamin A derivative (a retinoid) was intermittently administered. Multiple cancer including SPCC subsequently developed in the lower gingiva. We investigated the case histologically and immunohistologically based on the concept of field cancerization.
梭形细胞癌（SPCC）是一种相对罕见的肿瘤，被归类为鳞状细胞癌（SCC）的一种亚型。在组织学上，SPCC由一个SCC区域和具有间充质分化的上皮来源的梭形细胞组成。我们遇到了一例包括SPCC在内的多原发癌的有趣病例。在我们首次检查前13年发现了一个组织病理学上非典型的乳头状病变。随后口腔黏膜出现多个疣状白斑，为此间歇性给予口服维生素A衍生物（一种维甲酸）。随后在下牙龈发生了包括SPCC在内的多原发癌。我们基于场癌化的概念对该病例进行了组织学和免疫组织化学研究。
