Dunlop Anne L, Taylor Robert N, Tangpricha Vin, Fortunato Stephen, Menon Ramkumar
Department of Family & Preventive Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Infect Dis Obstet Gynecol. 2011;2011:216217. doi: 10.1155/2011/216217. Epub 2011 Dec 8.
To investigate associations among serum 25-hydroxy-vitamin D (25-OH-D), folate, omega-6/omega-3 fatty acid ratio and bacterial vaginosis (BV) during pregnancy.
Biospecimens and data were derived from a random sample (N = 160) of women from the Nashville Birth Cohort. We compared mean plasma nutrient concentrations for women with and without BV during pregnancy (based on Nugent score ≥7) and assessed the odds of BV for those with 25-OH-D <12 ng/mL, folate <5 ug/L, and omega-6/omega-3 ratio >15.
The mean plasma 25-OH-D was significantly lower among women with BV during pregnancy (18.00±8.14 ng/mL versus 24.34±11.97 ng/mL, P = 0.044). The adjusted odds of BV were significantly increased among pregnant women with 25-OH-D <12 ng/mL (aOR 5.11, 95% CI: 1.19-21.97) and folate <5 ug/L (aOR 7.06, 95% CI: 1.07-54.05).
Vitamin D and folate deficiencies were strongly associated with BV (Nugent score ≥7) during pregnancy.
探讨孕期血清25-羟基维生素D（25-OH-D）、叶酸、ω-6/ω-3脂肪酸比值与细菌性阴道病（BV）之间的关联。
生物标本和数据来自纳什维尔出生队列中随机抽取的160名女性样本。我们比较了孕期有和没有BV的女性（基于 Nugent 评分≥7）的平均血浆营养素浓度，并评估了25-OH-D<12 ng/mL、叶酸<5 μg/L和ω-6/ω-3比值>15的女性患BV的几率。
孕期患有BV的女性血浆25-OH-D平均水平显著较低（18.00±8.14 ng/mL对24.34±11.97 ng/mL，P = 0.044）。25-OH-D<12 ng/mL（调整后比值比5.11，95%可信区间：1.19-21.97）和叶酸<5 μg/L（调整后比值比7.06，95%可信区间：1.07-54.05）的孕妇患BV的调整后几率显著增加。
孕期维生素D和叶酸缺乏与BV（Nugent评分≥7）密切相关。
