孕期母体维生素D、叶酸和多不饱和脂肪酸状况与细菌性阴道病
Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy.
作者信息
Dunlop Anne L, Taylor Robert N, Tangpricha Vin, Fortunato Stephen, Menon Ramkumar
机构信息
Department of Family & Preventive Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Infect Dis Obstet Gynecol. 2011;2011:216217. doi: 10.1155/2011/216217. Epub 2011 Dec 8.
Abstract
OBJECTIVE
To investigate associations among serum 25-hydroxy-vitamin D (25-OH-D), folate, omega-6/omega-3 fatty acid ratio and bacterial vaginosis (BV) during pregnancy.
METHODS
Biospecimens and data were derived from a random sample (N = 160) of women from the Nashville Birth Cohort. We compared mean plasma nutrient concentrations for women with and without BV during pregnancy (based on Nugent score ≥7) and assessed the odds of BV for those with 25-OH-D <12 ng/mL, folate <5 ug/L, and omega-6/omega-3 ratio >15.
RESULTS
The mean plasma 25-OH-D was significantly lower among women with BV during pregnancy (18.00±8.14 ng/mL versus 24.34±11.97 ng/mL, P = 0.044). The adjusted odds of BV were significantly increased among pregnant women with 25-OH-D <12 ng/mL (aOR 5.11, 95% CI: 1.19-21.97) and folate <5 ug/L (aOR 7.06, 95% CI: 1.07-54.05).
CONCLUSION
Vitamin D and folate deficiencies were strongly associated with BV (Nugent score ≥7) during pregnancy.
摘要
目的
探讨孕期血清25-羟基维生素D（25-OH-D）、叶酸、ω-6/ω-3脂肪酸比值与细菌性阴道病（BV）之间的关联。
方法
生物标本和数据来自纳什维尔出生队列中随机抽取的160名女性样本。我们比较了孕期有和没有BV的女性（基于 Nugent 评分≥7）的平均血浆营养素浓度，并评估了25-OH-D<12 ng/mL、叶酸<5 μg/L和ω-6/ω-3比值>15的女性患BV的几率。
结果
孕期患有BV的女性血浆25-OH-D平均水平显著较低（18.00±8.14 ng/mL对24.34±11.97 ng/mL，P = 0.044）。25-OH-D<12 ng/mL（调整后比值比5.11，95%可信区间：1.19-21.97）和叶酸<5 μg/L（调整后比值比7.06，95%可信区间：1.07-54.05）的孕妇患BV的调整后几率显著增加。
结论
孕期维生素D和叶酸缺乏与BV（Nugent评分≥7）密切相关。
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