Department of Cancer Research and Molecular Medicine, Faculty of Medicine, MTFS, Norwegian University of Science and Technology, NTNU, Olav Kyrres gate 9, 7489 Trondheim, Norway.
PPAR Res. 2011;2011:436358. doi: 10.1155/2011/436358. Epub 2011 Dec 5.
This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months. Bone markers in plasma, whole body and femoral bone mineral density and content (BMD and BMC), and body composition were examined. Histomorphometric and biomechanical analyses (Study I) and biomechanical and μCT analyses (Study II) of the femur were performed. Normal rats fed TTA had higher femoral BMD and increased total and cortical area in femur compared to controls. The ovariectomized groups had decreased BMD and impaired microarchitecture parameters compared to SHAM. However, the TTA OVX group maintained femoral BMC, trabecular thickness in the femoral head, and cortical volume in the femoral metaphysis as SHAM. TTA might increase BMD and exert a light preventive effect on estrogen-related bone loss in rats.
本研究探讨了过氧化物酶体增殖物激活受体（PPAR）全激动剂十四烷硫代乙酸（TTA）对骨骼的影响。大鼠分为未去卵巢（研究 I）、去卵巢（OVX）或假手术（研究 II）三组，分别给予 TTA 或载体每日灌胃 4 个月。检测了血浆、全身和股骨骨矿物质密度和含量（BMD 和 BMC）以及体成分中的骨标志物。对股骨进行了组织形态计量学和生物力学分析（研究 I）以及生物力学和 μCT 分析（研究 II）。正常大鼠给予 TTA 后，股骨 BMD 较高，股骨总骨面积和皮质骨面积增加。与 SHAM 组相比，去卵巢组的 BMD 降低，微结构参数受损。然而，TTA OVX 组维持了股骨 BMC、股骨头的小梁厚度和股骨干骺端的皮质体积与 SHAM 组相似。TTA 可能会增加 BMD，并对大鼠的雌激素相关骨丢失产生轻度预防作用。
