精索静脉结扎术能否改善性腺功能减退和不育症男性的生育功能？一项前瞻性研究的分析。
Does varicocelectomy improve gonadal function in men with hypogonadism and infertility? Analysis of a prospective study.
机构信息
Department of Andrology, Ankur Health Care Private Limited, No. 55, 20th Main, 1st Block, Rajajinagar, Bengaluru 560010, India.
出版信息
Int J Endocrinol. 2011;2011:916380. doi: 10.1155/2011/916380. Epub 2011 Nov 29.
Abstract
Varicocele in infertile males is associated with Leydig cell dysfunction and hypogonadism. The effect of varicocelectomy on serum testosterone level is not yet established. We analysed 200 heterosexual infertile men diagnosed to have clinical varicocele they were divided into two groups: group 1 (100 men) had microsurgical varicocelectomy, and group 2 (100 patients) underwent assisted reproduction procedures. All participants had semen analysis, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and total testosterone (TT), measured both at recruitment time and 6 months later. In group 1, the mean TT level increased significantly after varicocelectomy (1.644 ± 0.029 to 2.461 ± 0.0198 ng/dL, P < 0.0001) and testicular size correlated with the mean change in TT (P = 0.001). No similar change was found in group 2. Out of the 100 patients in group 1, 78 had postoperative normalization of TT unlike only 16 men in group 2.
摘要
精索静脉曲张与睾丸间质细胞功能障碍和性腺功能减退症有关。精索静脉结扎术对血清睾酮水平的影响尚未确定。我们分析了 200 名被诊断为临床精索静脉曲张的异性恋不育男性，他们分为两组：第 1 组（100 名男性）接受了显微精索静脉结扎术，第 2 组（100 名患者）接受了辅助生殖程序。所有参与者均进行了精液分析、血清卵泡刺激素（FSH）、黄体生成素（LH）、催乳素和总睾酮（TT）水平的检测，分别在招募时和 6 个月后进行。在第 1 组中，精索静脉结扎术后 TT 水平显著升高（1.644±0.029 至 2.461±0.0198ng/dL，P<0.0001），睾丸大小与 TT 的平均变化相关（P=0.001）。第 2 组未发现类似变化。第 1 组 100 例患者中，78 例术后 TT 恢复正常，而第 2 组仅 16 例。
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