Stroke Registry of Dijon, Department of Neurology, University Hospital and Faculty of Medicine, Rue du Faubourg Raines, 21000 Dijon, France.
Alzheimer Dis Assoc Disord. 2012 Oct-Dec;26(4):307-13. doi: 10.1097/WAD.0b013e3182420b2c.
Although functional recovery and survival after ischemic stroke seem to improve in patients with prior transient ischemic attack (TIA), little is known about the effect of prior TIA on poststroke cognition. To evaluate the impact of prior TIA on dementia, 1697 nonaphasic patients who survived the first month after their first-ever ischemic stroke were identified from the population-based registry of Dijon, France, from 1985 to 2007 and divided into 3 groups according to the time interval between prior TIA and stroke (<4 wk, ≥4 wk, no TIA). Outcome was dementia diagnosed by neurologists using Diagnostic and Statistical Manual of mental disorders-III or IV criteria over the first month after stroke. Multivariate analyses were performed using logistic regression models. The prevalence of dementia after stroke was 20.6% [95% confidence interval (CI), 18.5-22.7], 26.8% (95% CI, 13.3-40.4), and 33.1% (95% CI, 27.3-38.9) among patients without TIA, with a prestroke TIA≥4 weeks, and with a prestroke TIA<4 weeks, respectively. Patients with prestroke TIA<4 weeks (adjusted odds ratio: 1.83; 95% CI, 1.32-2.52; P=0.0003) had a higher risk of dementia than those without TIA.
尽管有短暂性脑缺血发作（TIA）病史的缺血性脑卒中患者的功能恢复和生存似乎有所改善，但对于 TIA 对脑卒中后认知的影响知之甚少。为了评估 TIA 对痴呆的影响，从 1985 年至 2007 年，在法国第戎的人群登记处中确定了 1697 例首次发生缺血性脑卒中后存活 1 个月的非失语患者，并根据 TIA 与脑卒中之间的时间间隔将其分为 3 组（<4 周，≥4 周，无 TIA）。通过神经科医生使用精神障碍诊断和统计手册第 III 或 IV 版标准在脑卒中后 1 个月内诊断痴呆为结局。使用逻辑回归模型进行多变量分析。无 TIA、TIA 发作≥4 周和 TIA 发作<4 周的患者，脑卒中后痴呆的患病率分别为 20.6%（95%可信区间，18.5-22.7）、26.8%（95%可信区间，13.3-40.4）和 33.1%（95%可信区间，27.3-38.9）。TIA 发作<4 周的患者（调整后的优势比：1.83；95%可信区间，1.32-2.52；P=0.0003）痴呆的风险高于无 TIA 的患者。
