Zou Yan, Zhu Qinlan, Deng Yongtao, Duan Jingxi, Pan Ling, Tu Qi, Dai Rong, Zhang Xuemei, Chu Leung-Wing, Lü Yang
1Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Am J Alzheimers Dis Other Demen. 2014 May;29(3):242-7. doi: 10.1177/1533317513517042. Epub 2013 Dec 27.
Increasing evidence has demonstrated that vascular risk factors (VRFs) contribute to cognitive impairment in the elderly population. Prevention and administration of VRFs can be a vital strategy for delaying cognitive impairment. This study aimed to determine the impact of VRFs on cognitive function of the aged people from Chongqing, Southwest China.
A total of 597 participants (≥60 years) from hospital and community population were enrolled in the cross-sectional study. Participants were screened for hypertension, coronary heart disease (CHD), and cerebrovascular disease (CVD). Blood pressure (BP) and blood lipid were also measured. Cognitive function was assessed with Mini-Mental State Examination and Clinical Dementia Rating. Logistic regression analysis was used to look for VRFs impacting mild cognitive impairment (MCI). Then we investigated the relationship between different types of vascular diseases and MCI.
A total of 457 participants showed normal cognitive function and 140 participants showed MCI. After adjusting for age, gender, and education, logistic regression analysis demonstrated that hypertension, CHD, systolic BP, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) were independently associated with MCI; however, CVD, diastolic BP, triglyceride, and high-density lipoprotein cholesterol were not associated with MCI. Moreover, vascular diseases significantly contributed to MCI compared with no vascular disease; however, no significant difference in incident MCI was found among different combinations of vascular diseases.
Hypertension, CHD, TC, and LDL-C are independent risk factors for MCI. Moreover, patients with vascular diseases have a higher risk of MCI; however, the amount of vascular diseases does not increase the risk of MCI.
越来越多的证据表明，血管危险因素（VRFs）会导致老年人群认知功能障碍。预防和控制VRFs可能是延缓认知功能障碍的重要策略。本研究旨在确定VRFs对中国西南部重庆地区老年人认知功能的影响。
共有597名年龄≥60岁的医院和社区人群参与了这项横断面研究。对参与者进行高血压、冠心病（CHD）和脑血管疾病（CVD）筛查。同时测量血压（BP）和血脂。采用简易精神状态检查表和临床痴呆评定量表评估认知功能。使用逻辑回归分析寻找影响轻度认知障碍（MCI）的VRFs。然后我们研究了不同类型血管疾病与MCI之间的关系。
共有457名参与者认知功能正常，140名参与者存在MCI。在对年龄、性别和教育程度进行校正后，逻辑回归分析表明，高血压、CHD、收缩压、总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）与MCI独立相关；然而，CVD、舒张压、甘油三酯和高密度脂蛋白胆固醇与MCI无关。此外，与无血管疾病相比，血管疾病显著增加MCI风险；然而，不同血管疾病组合之间的MCI发病率无显著差异。
高血压、CHD、TC和LDL-C是MCI的独立危险因素。此外，患有血管疾病的患者发生MCI的风险更高；然而，血管疾病的数量并不会增加MCI的风险。
