Department of Biochemistry and Molecular Biology & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, China.
Acta Biochim Biophys Sin (Shanghai). 2012 Jan;44(1):48-53. doi: 10.1093/abbs/gmr108.
Pluripotent stem cells are able to proliferate unlimitedly and to generate all somatic cell types, thus holding a great promise in medical applications. Epigenetic modifications are believed to play crucial roles in regulating pluripotency and differentiation. Recent genome-wide studies on mammalian systems have revealed several types of large chromatin domains which are associated with higher-order organization of the genome. The elucidation of genomic distribution and dynamics of these domains have shed light on the mechanisms underling pluripotency and lineage commitment.
多能干细胞能够无限增殖并产生所有体细胞类型，因此在医学应用中具有很大的应用前景。表观遗传修饰被认为在调节多能性和分化中起着至关重要的作用。最近对哺乳动物系统的全基因组研究揭示了几种与基因组高级组织相关的大型染色质结构域。这些结构域的基因组分布和动态的阐明揭示了多能性和谱系决定的机制。
